Search results for "Glucose infusion"

showing 3 items of 3 documents

The pancreatic beta-cell response to intravenous administration of glucose in elderly subjects.

1970

A study was made of the serum insulin level after the intravenous administration of glucose (0.33 gm/ kg) in two groups of normal subjects—18 in the 60–85 age bracket, and 16 in the 23–45 age bracket. All had a normal coefficient of glucose utilization and a normal blood glucose curve after intravenous administration of glucose. Serum insulin was assayed by the radio-immunological method, with use of an ion exchange resin. Blood samples were drawn at 2, 5, 10, 30, 45 and 60 minutes after the end of the glucose infusion. In the elderly subjects the maximal value was reached only after 5 minutes and the mean value was 39± 9 µU/ml (range, 27–50), whereas in the younger subjects the serum insul…

AdultBlood GlucoseGlucose utilizationmedicine.medical_specialtymedicine.medical_treatmentRadioimmunoassayStimulationGlucose infusionInternal medicineMedicineHumansInsulinPancreasAgedbusiness.industryInsulinMean valueAge FactorsGlucose Tolerance TestMiddle AgedPeripheralEndocrinologyGlucoseInjections IntravenousGeriatrics and GerontologyBeta cellbusinessNormal blood glucoseJournal of the American Geriatrics Society
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Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice

2014

Objective: The C57Bl/6J (Bl/6J) mouse is the most widely used strain in metabolic research. This strain carries a mutation in nicotinamide nucleotide transhydrogenase (Nnt), a mitochondrial enzyme involved in NADPH production, which has been suggested to lead to glucose intolerance and beta-cell dysfunction. However, recent reports comparing Bl/6J to Bl/6N (carrying the wild-type Nnt allele) under normal diet have led to conflicting results using glucose tolerance tests. Thus, we assessed glucose-stimulated insulin secretion (GSIS), insulin sensitivity, clearance and central glucose-induced insulin secretion in Bl/6J and N mice using gold-standard methodologies. Methods: GSIS was measured u…

Genetically modified mouseFSIVGTT frequently sampled intravenous glucose tolerance testmedicine.medical_specialtylcsh:Internal medicineinsulin secretionNormal dietDI disposition indexOGTT oral glucose tolerance testmedicine.medical_treatment[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutritionbeta-cellBrief Communicationmedicine.disease_cause[ SDV.BA ] Life Sciences [q-bio]/Animal biologyGSIS glucose-stimulated insulin secretiongenetic backgroundGIR glucose infusion rateInternal medicinemedicineInsulin-degrading enzymeIDE insulin degrading enzymeFood and Nutritioninsulin sensitivityInsulin secretionlcsh:RC31-1245Molecular BiologyEndocrinology and metabolismMutationMI insulin sensitivity indexbusiness.industryInsulin[SDV.BA]Life Sciences [q-bio]/Animal biologyInsulin sensitivityCell BiologyNNT nicotinamide nucleotide transhydrogenaseEndocrinologyIVGTT intravenous glucose tolerance testAlimentation et NutritionEndocrinologie et métabolismemouse strainBeta cellbusiness[SDV.AEN]Life Sciences [q-bio]/Food and Nutritionbeta-cell;insulin secretion;insulin sensitivity;genetic background;mouse strain
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Long-term stability study of clofarabine injection concentrate and diluted clofarabine infusion solutions

2011

Purpose: The aim of this study was to investigate the physicochemical stability of clofarabine (CAFdA) injection concentrate and ready-to-use CAFdA infusion solutions over a prolonged period of 28 days. Methods: To determine the stability of CAFdA infusion solutions, the injection concentrate (Evoltra®, 1 mg/mL, Genzyme) was diluted either with 0.9% sodium chloride or 5% glucose infusion solution. The resulting concentrations of 0.2 mg/mL or 0.6 mg/mL, respectively, were chosen to represent the lower and upper limit of the ordinary concentration range. Test solutions were stored under refrigeration (2–8°C) or at room temperature either light protected or exposed to light. CAFdA concentrati…

Time FactorsStability studyDrug StorageSodiumchemistry.chemical_elementAntineoplastic AgentsInjection concentratechemistry.chemical_compoundGlucose infusionDrug StabilitymedicineClofarabinePharmacology (medical)Clofarabine InjectionInfusions IntravenousChromatography High Pressure LiquidChromatographyAdenine Nucleotidesbusiness.industryReproducibility of ResultsPolyethylenePharmaceutical SolutionsPolyvinyl chlorideOncologychemistryArabinonucleosidesbusinessClofarabinemedicine.drugJournal of Oncology Pharmacy Practice
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